Please be aware that Rome has multiple airports and that these results are for all airports serving the city.
The best month to arrive at Rome is January and the most expensive month to fly is December. (Average prices, based on 684 datapoints.)
The best day to arrive at Rome is Wednesday and it would be best to avoid Saturday, as prices are on average 46.5% higher than on Wednesday. (Average prices, based on 755 datapoints.)
The cheapest airline flying to Rome is TAP Portugal. They are 80% cheaper than British Airways. (Average prices, based on 767 datapoints.)
At Rome the most flights depart around 11:00. (Hourly flights, based on 1042 datapoints.)
From Rome it is on average the cheapest to fly to Milan and to Eindhoven. (Average prices, based on 131 datapoints.)
From Rome most of the flights depart to London, second best connected from Rome is Milan. (Daily flights, based on 128 datapoints.)